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General
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Burden of chronic diseases associated with periodontal diseases: a retrospective cohort study using UK primary care data
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In this cohort, periodontal diseases appeared to be associated with an increased risk of developing cardiovascular, cardiometabolic, autoimmune diseases and mental ill health. Periodontal diseases are very common; therefore, an increased risk of other chronic diseases represent a substantial public health burden.
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BMJ Journals
|
2021
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General
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Human variation in gingival inflammation
Article: Study reveals new aspects of gingivitis and the body’s response
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Sheds important new light on why some people may be more prone to serious conditions that lead to tooth loss and other problems.
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PNAS
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2021
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General
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Dental Services and Health Outcomes in the New York State Medicaid Program
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Observed that accessing preventive dental care by a large cohort of publicly insured individuals in New York State was associated with better health care outcomes, most notably for the rates and costs of inpatient admissions.
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Journal of Dental Research
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2021
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General
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Periodontal Inflammation Primes the Systemic Innate Immune Response
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Provides clinical rationale for perio-systemic disease links
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Journal of Dental Research
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2020
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General
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Current Knowledge on Correlations Between Highly Prevalent Dental Conditions and Chronic Diseases: An Umbrella Review
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Provides support of correlative; not causative perio-systemic links
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CDC – Systematic Review (Volume 16)
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2019
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Topic
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Title and Link
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Brief Description
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Journal
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Date
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Diabetes
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Number of teeth and masticatory function are associated with sarcopenia and diabetes mellitus status among community-dwelling older adults: A Shimane CoHRE study
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Findings suggest that improvement in oral health, including the maintenance of masticatory function and remaining teeth, may contribute to the prevention of sarcopenia and diabetes mellitus in older adults.
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PLOS One
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2021
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Diabetes
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The risk of tooth loss in patients with diabetes: a systematic review and meta-analysis
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There is moderate certainty for a small but significantly higher risk of tooth loss in Diabetes patients as compared to those without Diabetes.
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International Journal of Dental Hygiene
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2021
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Diabetes
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Effect of Diabetes on Rotary Instrumentation of Dentin
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Diabetes mellitus may affect the physical and mechanical properties of dentin, which could potentially have an impact on root canal procedures.
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Journal of Endodontics
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2021
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Diabetes
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Implementation of an Oral Care Protocol for Primary Diabetes Care: A Pilot Cluster-Randomized Controlled Trial
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Implementation of an oral care protocol in primary diabetes care improved oral health–related quality of life in patients with type 2 diabetes
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Annals of Family Medicine
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2021
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Diabetes
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Improved oral hygiene is associated with decreased risk of new-onset
diabetes: a nationwide population-based cohort study
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Provides evidence that oral hygiene reduces new onset T2D
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Springer Verlag
|
2020
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Diabetes
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Does diabetes increase the risk of periodontitis? A systematic review and meta-regression analysis of longitudinal prospective studies
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Provides evidence that diabetes increases perio risk
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National Library of Medicine
|
2018
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Diabetes
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The effect of periodontal therapy on glycemic control and fasting plasma glucose level in type 2 diabetic patients
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In this systematic review and meta-analysis, there is a significant reduction of Glycated hemoglobin and Fasting plasma glucose level on type 2 diabetic and periodontal patients with non-surgical periodontal therapy.
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BMC Oral Health
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2016
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Diabetes
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Evidence that periodontal treatment improves diabetes outcomes: a systematic review and meta-analysis.
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Supporting evidence that perio treatment improves T2D control
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Journal of Clinical Periodontology
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2013
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Diabetes
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Effect of periodontal disease on diabetes: systematic review of epidemiologic observational evidence
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Provides evidence to suggest that perio disease adversely affects diabetes outcomes
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Journal of Clinical Periodontology
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2013
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Topic
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Title and Link
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Brief Description
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Journal
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Date
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Cardiovascular disease
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Burden of chronic diseases associated with periodontal diseases: a retrospective cohort study using UK primary care data
|
In this cohort, periodontal diseases appeared to be associated with an increased risk of developing cardiovascular, cardiometabolic, autoimmune diseases and mental ill health.
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BMJ Open
|
2022
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Cardiovascular disease
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Severe Periodontal Disease Increases Acute Myocardial Infarction and Stroke: A 10-Year Retrospective Follow-up Study
Articles:
· Severe Periodontal Disease Increases Risk of Acute Myocardial Infarction and Stroke: Study
|
This study aimed to evaluate the causal association of periodontal disease with acute myocardial infarction (AMI) and stroke, after controlling for various confounders among the Korean population. Our data confirmed that severe periodontal disease was causally associated with the new events of AMI and stroke.
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Journal of Dental Research
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2021
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Cardiovascular disease
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Pre-cardiac dental treatment does not increase the risk of adverse events
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The results of this study suggest that elimination of oral infection prior to cardiovascular surgery does not increase the risk of morbidity or mortality.
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Journal of Oral and Maxillofacial Surgery
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2021
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Cardiovascular disease
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Oral Bacterial Signatures in Cerebral Thrombi of Patients With Acute Ischemic Stroke Treated With Thrombectomy
Articles:
· AHA News: How Oral Health May Affect Your Heart, Brain and Risk of Death
· Dental cavities can raise risk of heart disease, stroke, according to scientists
|
Streptococcal bacteria, mostly of oral origin, may contribute to the progression and thrombotic events of cerebrovascular diseases.
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Journal of the American Heart Association
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2021
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Cardiovascular disease
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Periodontal Disease, Atrial Fibrillation and Stroke
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Those who kept up with routine dental care had lower risks of atrial fibrillation than those who only went to the dentist when they experienced discomfort or needed dental work or who failed to keep a regular appointment schedule
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American Heart Journal
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2021
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Cardiovascular disease
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Association Between Periodontitis and Blood Pressure Highlighted in Systemically Healthy Individuals
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Study aimed to investigate the relationship between periodontitis and mean arterial blood pressure in a sample of otherwise systemically healthy individuals.
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Hypertension
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2021
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Cardiovascular disease
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Associations of Antibodies Targeting Periodontal Pathogens with Subclinical Coronary, Carotid, and Peripheral Arterial Atherosclerosis in Rheumatoid Arthritis
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Rheumatoid arthritis (RA) patients have elevated rates of perio and cardiovascular disease, suggesting that their immune responses to gum disease bacteria may be linked to higher heart disease risk.
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Arthritis and Rheumatology
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2020
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Cardiovascular disease
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Abstract P441: Dental Caries a Risk Factor for Intracerebral Hemorrhage
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Reports a significant association between dental caries and intracerebral hemorrhage (ICH).
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Stroke
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2021
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Cardiovascular disease
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Periodontitis and atherosclerotic cardiovascular disease: consensus report of the Joint EFP/AAP Workshop on Periodontitis and Systemic Diseases.
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Provides consistent and strong epidemiologic evidence that periodontitis increased risk for future cardiovascular disease
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Journal of Clinical Periodontology
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2013
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Topic
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Title and Link
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Brief Description
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Journal
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Date
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Pregnancy
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Adverse pregnancy outcomes and periodontitis: A systematic review and meta-analysis exploring potential association.
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Systematic review supports a low but existing association between perio and adverse pregnancy outcomes
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National Library of Medicine
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2016
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Pregnancy
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Oral Health in Pregnancy
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In this article we describe the importance of the recognition, prevention, and treatment of oral health problems in pregnant women.
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Journal of Obstetric, Gynecologic, & Neonatal Nursing (JOGNN)
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2016
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Pregnancy
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Periodontitis and adverse pregnancy outcomes: consensus report of the Joint EFP/AAP Workshop on Periodontitis and Systemic Diseases.
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Aims to assess epidemiological evidence for the impact of perio disease on adverse pregnancy outcomes and identify potential underlying mechanisms.
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Journal of Clinical Periodontology
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2013
|
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Topic
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Title and Link
|
Brief Description
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Journal
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Date
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Alzheimer’s Disease and dementia
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Dose-Response Meta-Analysis on Tooth Loss With the Risk of Cognitive Impairment and Dementia
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Moderate-quality evidence suggested tooth loss was independently associated with cognitive impairment and dementia; risk of diminished cognitive function increased with incremental numbers of teeth lost. Further, timely prosthodontic treatment with dentures may reduce the progression of cognitive decline related to tooth loss.
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Journal of Post-Acute and Long-Term Care Medicine
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2021
|
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Alzheimer’s Disease and dementia
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Obstructive sleep apnea treatment and dementia risk in older adults
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PAP treatment and adherence are independently associated with lower odds of incident AD diagnoses in older adults. Results suggest that treatment of OSA may reduce the risk of subsequent dementia.
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Sleep
|
2021
|
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Alzheimer’s Disease and dementia
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Association between number of teeth and Alzheimer’s disease using the National Database of Health Insurance Claims and Specific Health Checkups of Japan
|
The results of the present study using Japanese dental claims data showed that older people visiting dental offices with fewer teeth present and a greater number of missing teeth are more likely to have Alzheimer’s disease.
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PLOS One
|
2021
|
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Alzheimer’s Disease and dementia
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Periodontal dysbiosis associates with reduced CSF Aβ42 in cognitively normal elderly
|
To our knowledge, this is the first report of an association between subgingival periodontal bacteria and CSF biomarkers of AD pathology in cognitively normal elderly people. We found that subgingival periodontal dysbiosis characterized by increases in periodontal‐associated bacteria and decreases in health‐related bacteria associated with reduced CSF Aβ42 but not with CSF P‐tau.
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Alzheimer’s Association
|
2021
|
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Alzheimer’s Disease and dementia
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Periodontal disease and incident dementia: The Atherosclerosis Risk in Communities Study (ARIC)
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Supports a modest association between perio disease and incidence of mild cognitive impairment and dementia
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Neurology – American Academy of Neurology
|
2020
|
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Alzheimer’s Disease and dementia
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Clinical and Bacterial Markers of Periodontitis and Their Association with Incident All-Cause and Alzheimer's Disease Dementia in a Large National Survey
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This study provides evidence for an association between periodontal pathogens and AD, which was stronger for older adults.
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Journal of Alzheimer’s Disease
|
2020
|
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Alzheimer’s Disease and dementia
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Porphyromonas gingivalis in Alzheimer’s disease brains: Evidence for disease causation and treatment with small-molecule inhibitors
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Evaluates the mechanisms underlying the potential link between perio disease and Alzheimer’s disease
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Science Advances -- American Assoc for the Advancement of Science
|
2019
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Alzheimer’s Disease and dementia
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Association between Periodontitis and Alzheimer's Disease
|
Evaluates the potential link between perio disease and Alzheimer’s disease with goal of identifying novel mechanisms and interventional strategies to improve patient outcomes
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NIH – US Library of Medicine
|
2015
|
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Topic
|
Title and Link
|
Brief Description
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Journal
|
Date
|
|
Osteoporosis
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The Association between Bone Mineral Density and Periodontal Disease in Middle-Aged Adults
|
Low bone mass was associated with the risk of Periodontal Disease among young adults
|
International Journal of Environmental Research and Public Health
|
2021
|
|
Osteoporosis
|
Oral implications of osteoporosis
|
Evidence from (97) prospective studies
supports the contention that individuals with osteoporosis may be at increased risk for the manifestations of oral osteoporosis;
however, such risk is not definitively proven.
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Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology
|
2005
|
|
Topic
|
Title and Link
|
Brief Description
|
Journal
|
Date
|
|
Kidney Disease
|
Periodontal Disease and Incident CKD in US Hispanics/Latinos: The Hispanic Community Health Study/Study of Latinos
Article: Periodontal disease linked to kidney function decline in Hispanic, Latino patients
|
Found that select measures of periodontal disease were associated with incident low estimated glomerular filtration rate (eGFR)
|
Kidney Medicine
|
2021
|
|
Kidney Disease
|
Oral conditions in renal disorders and treatment considerations – A review for pediatric dentists
|
This article reviews the current understanding of the oral and dental aspects of chronic renal disease (CRD).
|
The Saudi Dental Journal
|
2015
|
|
Topic
|
Title and Link
|
Brief Description
|
Journal
|
Date
|
|
Psoriasis
|
Psoriasis Patients Suffer From Worse Periodontal Status—A Meta-Analysis
|
The aim of this meta-analysis was to quantitatively evaluate whether the periodontal status of psoriasis patients is worse than that of nonpsoriasis subjects.
|
Frontiers in Medicine
|
2019
|
|
Topic
|
Title and Link
|
Brief Description
|
Journal
|
Date
|
|
Anxiety and Depression
|
Burden of chronic diseases associated with periodontal diseases: a retrospective cohort study using UK primary care data
|
In this cohort, periodontal diseases appeared to be associated with an increased risk of developing cardiovascular, cardiometabolic, autoimmune diseases and mental ill health.
|
BMJ Open
|
2022
|
|
Anxiety and Depression
|
Institutionalized old people, depressive disorders, and dental issues: what is the state of the art?
|
The present study identified that there is a communication between some oral health conditions (xerostomia and tooth loss) and the prevalence of depressive disorders in institutionalized old people.
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SciFlo Brazil
|
2021
|
|
Anxiety and Depression
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Relationship between cognitive impairment and oral health: results of the Health 2000 Health Examination Survey in Finland
|
Cognitively impaired subjects among older adults in Finland have more carious teeth, are more often edentulous without using a denture, and have poorer denture hygiene than cognitively healthy persons.
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Taylor and Francis Online
|
2021
|
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Anxiety and Depression
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Relationship between chronic gingivitis and subsequent depression in 13,088 patients followed in general practices
|
There was a positive and significant association between chronic gingivitis and depression in the overall sample. These findings were corroborated in men and women and in all age groups except patients 65+ years.
|
Journal of Psychiatric Research
|
2021
|
|
Anxiety and Depression
|
Oral health condition and occurrence of depression in the elderly
|
The results of our study have shown that among people aged 65 and over, the severity of depression increases with a higher number of missing teeth, the number of decayed teeth, as well as prevalence of oral dryness.
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Medicine
|
2018
|
|
Topic
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Title and Link
|
Brief Description
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Journal
|
Date
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|
Arthritis
|
Dental Amalgams and the Incidence Rate of Arthritis among American Adults
Articles:
· New Research Links Dental Amalgam Mercury Fillings To Arthritis
|
This hypothesis-testing study evaluated the relationship between mercury (Hg)-based dental amalgams and arthritis diagnoses among US adults. A significant association between dental amalgam filling surface (DAFS) and arthritis risk and a dose-dependent DAFS associated immune-stimulation / immune-suppression with arthritis risk were observed.
|
Clinical Medicine Insights: Arthritis and Musculoskeletal Disorders
|
2021
|
|
Arthritis
|
The oral microbiome in early rheumatoid arthritis patients and individuals at risk differs from healthy controls
Articles
· Do bacteria in the mouth affect arthritis risk?
· Oral Microbiome Linked to Onset of Rheumatoid Arthritis
|
The results show similarities in the oral microbiome between ERA patients and at-risk individuals, both presenting with increased relative abundance of potentially pro-inflammatory species compared to healthy controls, suggesting a possible association between the oral microbiome and RA onset.
|
Arthritis Rheumatol
|
2021
|
|
Arthritis
|
Associations of Antibodies Targeting Periodontal Pathogens with Subclinical Coronary, Carotid, and Peripheral Arterial Atherosclerosis in Rheumatoid Arthritis
|
Rheumatoid arthritis (RA) patients have elevated rates of periodontal and cardiovascular disease, suggesting that their immune responses to gum disease bacteria may be linked to higher heart disease risk.
|
Arthritis and Rheumatology
|
2020
|
|
Arthritis
|
Periodontitis as the risk factor of chronic kidney disease: Mediation analysis
|
Aims to determine sequences and magnitude of causality among perio disease, diabetes and chronic kidney disease
|
Journal of Clinical Periodontology
|
2019
|
|
Arthritis
|
Oral conditions in renal disorders and treatment considerations – A review for pediatric dentist
|
This article reviews the current understanding of the oral and dental aspects of chronic renal disease (CRD).
|
Saudi Dental Journal (republished on US National Library of Medicine -- NIH)
|
2015
|
|
Arthritis
|
Periodontal disease and rheumatoid arthritis: the evidence accumulates for complex pathobiologic interactions
|
Evaluates the potential link between perio disease and rheumatoid arthritis with goal of identifying novel mechanisms and interventional strategies to improve patient outcomes
|
NIH – US Library of Medicine
|
2013
|
|
Topic
|
Title and Link
|
Brief Description
|
Journal
|
Date
|
|
Cancer
|
Mouth pathogens may trigger oral squamous cell carcinoma
|
Evaluates the impact of periodontal disease on the development of oral cancer
|
PLOS Pathogen
|
2020
|
|
Cancer
|
Periodontal Disease, Tooth Loss, and Risk of Serrated Polyps and Conventional Adenomas
|
Concludes that a history of perio disease and possibly higher number of tooth loss may modestly increase the risk of developing colorectal precursor lesions.
|
American Association for Cancer Research
|
2020
|
|
Cancer
|
Certain oral bacteria linked to higher risk for esophageal cancer
|
Oral bacteria appeared to be more abundant in patients with esophageal cancer compared with otherwise healthy controls
|
Cancer (American Cancer Society)
|
2020
|
|
Cancer
|
Periodontal Disease Assessed Using Clinical Dental Measurements and Cancer Risk in the ARIC Study
|
Provides additional evidence that cancer risk, especially for lung and colorectal cancer, is elevated in individuals with perio disease.
|
Journal of the National Cancer Institute
|
2018
|
|
Cancer
|
Periodontal Treatment in Cancer Patients: An Interdisciplinary Approach
|
Provides a review of the literature to determine the relationships between dental care in the cancer patient to provide strategic suggestions.
|
NIH -- US Library of Medicine
|
2018
|
|
Cancer
|
Periodontal therapy for patients before and after radiotherapy: A review of the literature and topics of interest for clinicians
|
Reviews appropriate care strategies (perio maintenance, extractions) before and after head and neck cancer treatment and strategies to prevent osteoradionecrosis.
|
NIH -- US Library of Medicine
|
2018
|
|
Cancer
|
Periodontal Disease and Incident Cancer Risk among Postmenopausal Women: Results from the Women's Health Initiative Observational Cohort
|
Study findings support the need for further understanding of the effect of periodontal disease on cancer outcomes
|
Cancer Epidemiology,
Biomarkers & Prevention
|
2017
|
|
|
VARIOUS RELEVANT ARTICLES
RESEARCHERS EXAMINE THE “ORAL MICROBIOME” TO LOOK FOR CLUES TO CANCER RISK.
STUDY: WOMEN WITH PERIODONTAL DISEASE HAD HIGHER RISK OF SEVERAL CANCER TYPES.
IN A STUDY, RESEARCHERS FOUND AN ASSOCIATION BETWEEN PERIODONTAL DISEASE, TOOTH LOSS, AND CONDITIONS ASSOCIATED WITH COLORECTAL CANCER.
|
|
Topic
|
Title and Link
|
Brief Description
|
Journal
|
Date
|
|
Other connections
|
Athletics
The impact of oral health on physical fitness: A systematic review
|
Oral health problems may have numerous effects on general health, including physical fitness and performance. In this review, we aimed to systematically review the available evidence to assess the effect of oral health on general physical fitness.
|
Heliyon
|
2020
|
|
Other connections
|
Asthma
Association between asthma and periodontal disease: A systematic review and meta-analysis
|
Data from this systematic review strongly suggest the association of asthma with periodontal disease.
|
Journal of Periodontology
|
2018
|
|
Other connections
|
COVID
Alveolar bone loss and tooth loss are associated with COVID-19 severity but are not independent risk factors. An explorative study
|
In this retrospective explorative pilot study, alveolar bone loss and tooth loss are associated with the severity of COVID-19, however they are not independent risk factors.
|
Advances in Oral and Maxillofacial Surgery
|
2021
|
|
Other connections
|
Auto-immune
Burden of chronic diseases associated with periodontal diseases: a retrospective cohort study using UK primary care data
|
In this cohort, periodontal diseases appeared to be associated with an increased risk of developing cardiovascular, cardiometabolic, autoimmune diseases and mental ill health.
|
BMJ Open
|
2022
|